Study of Danicopan as Add-on Treatment to Ravulizumab or Eculizumab in Pediatric Participants With PNH Who Have Clinically Significant Extravascular Hemolysis
Study Identifier:
D7332C00006
ClinicalTrials.gov Identifier:
EudraCT Identifier:
N/A
EU CT ID:
N/A
Sponsor:
Alexion Pharmaceuticals, Inc.
Study Contact Information:
Recruiting
Study Details
Medical Condition
- Paroxysmal Nocturnal Hemoglobinuria
- PNH
- Extravascular Hemolysis
Study Drug
- Drug: Danicopan
Date
Aug 2025 - May 2027
Phase 1
Phase 2
Phase 3
Phase 4
N/A
Patient Requirements
Sex: Female & Male
Age: 12 - 17 Years
Requirements Information
Inclusion and Exclusion Criteria
Inclusion Criteria
- Confirmed diagnosis of PNH.
- CS-EVH defined by: Anemia: Hgb ≤ 10.5 g/dL, and absolute reticulocyte count ≥ 100 × 109/L
- Treated with ravulizumab or eculizumab for at least 12 weeks immediately preceding Day 1, the dose received should be stable during this period, and there should be no anticipated changes in dosage or interval during the first 12 weeks of this study.
- all participants must be vaccinated against meningococcal infection from serogroups A, C, W, and Y and serogroup B within 3 years prior to, or at least 14 days prior to Day 1
- vaccinated against Haemophilus influenzae type b (Hib) and Streptococcus pneumoniae
Exclusion Criteria
- Platelet count \< 30000/μL or there is a need for platelet transfusions.
- ANC \< 500/μL.
- Clinically significant laboratory abnormalities related to liver function, including:
- ALT \> 2 × ULN or ALT \> 3 × ULN for participants with documented liver iron overload defined by serum ferritin values ≥ 500 ng/mL.
- Direct bilirubin \> 2 × ULN, unless, in the Investigator's opinion, is due to hemolysis or Gilbert's syndrome based on medical history.
- Current evidence of biliary cholestasis.
- Known aplastic anemia or other bone marrow failure that requires HSCT or other therapies, including anti-thymocyte globulin and immunosuppressants unless the dosage of immunosuppressant has been stable for at least 12 weeks before Day 1 and is expected to remain stable through Week 12.
- History of a major organ transplant (eg, heart, lung, kidney, liver) or HSCT.
- Known or suspected complement deficiency.
- Active bacterial or viral infection, a body temperature \> 38°C on 2 consecutive daily measures, evidence of other infection, or history of any febrile illness within 14 days prior to first study intervention administration.
Sex
Female & Male
Age
12 - 17 Years
Study Details
Medical Condition
- Paroxysmal Nocturnal Hemoglobinuria
- PNH
- Extravascular Hemolysis
Study Drug
- Drug: Danicopan
Date
Aug 2025 - May 2027
Phase 1
Phase 2
Phase 3
Phase 4
N/A
Patient Requirements
Sex: Female & Male
Age: 12 - 17 Years years
Requirements Information
Inclusion and Exclusion Criteria
Inclusion Criteria
- Confirmed diagnosis of PNH.
- CS-EVH defined by: Anemia: Hgb ≤ 10.5 g/dL, and absolute reticulocyte count ≥ 100 × 109/L
- Treated with ravulizumab or eculizumab for at least 12 weeks immediately preceding Day 1, the dose received should be stable during this period, and there should be no anticipated changes in dosage or interval during the first 12 weeks of this study.
- all participants must be vaccinated against meningococcal infection from serogroups A, C, W, and Y and serogroup B within 3 years prior to, or at least 14 days prior to Day 1
- vaccinated against Haemophilus influenzae type b (Hib) and Streptococcus pneumoniae
Exclusion Criteria
- Platelet count \< 30000/μL or there is a need for platelet transfusions.
- ANC \< 500/μL.
- Clinically significant laboratory abnormalities related to liver function, including:
- ALT \> 2 × ULN or ALT \> 3 × ULN for participants with documented liver iron overload defined by serum ferritin values ≥ 500 ng/mL.
- Direct bilirubin \> 2 × ULN, unless, in the Investigator's opinion, is due to hemolysis or Gilbert's syndrome based on medical history.
- Current evidence of biliary cholestasis.
- Known aplastic anemia or other bone marrow failure that requires HSCT or other therapies, including anti-thymocyte globulin and immunosuppressants unless the dosage of immunosuppressant has been stable for at least 12 weeks before Day 1 and is expected to remain stable through Week 12.
- History of a major organ transplant (eg, heart, lung, kidney, liver) or HSCT.
- Known or suspected complement deficiency.
- Active bacterial or viral infection, a body temperature \> 38°C on 2 consecutive daily measures, evidence of other infection, or history of any febrile illness within 14 days prior to first study intervention administration.
Protocol Summary
The primary objective of this study is to evaluate efficacy of danicopan as add-on treatment to ravulizumab or eculizumab as assessed by hemoglobin (Hgb) change from Baseline at Week 12 in pediatric participants with paroxysmal nocturnal hemoglobinuria (PNH) and clinically significant extravascular hemolysis (CS-EVH).
Trial Locations
Location
Status
Location
Research Site
Saskatoon, Saskatchewan, Canada, S7N 0W8
Status
Not yet recruiting
Location
Research Site
Paris, France, 77019
Status
Recruiting
Location
Research Site
Leeds, United Kingdom, LS9 7TF
Status
Not yet recruiting
Location
Research Site
London, United Kingdom, SE5 9RS
Status
Not yet recruiting