Evaluation of the Safety and Efficacy of Eneboparatide (AZP-3601) in Patients With Chronic Hypoparathyroidism

Study Identifier:
AZP-3601-CLI-002
ClinicalTrials.gov Identifier:
NCT05778071
EudraCT Identifier:
N/A
EU CT ID:
N/A
Sponsor:
Alexion Pharmaceuticals, Inc.
Study Contact Information:
N/A
Recruitment Complete

Study Details

Medical Condition
  • Unmapped
Study Drug
    Date
    Jun 2023 - Nov 2024
    Phase 1
    Phase 2
    Phase 3
    Phase 4
    N/A
    Patient Requirements
    Sex: Female & Male
    Age: 18 - 80 Years
    Requirements Information
    Inclusion and Exclusion Criteria
    Inclusion Criteria
    • Males and Females, 18-80 years of age
    • Patients with cHP for ≥12 months at the time of screening
    • Two paired measurements of showing low parathyroid hormone (PTH) and serum calcium either below normal or within normal under standard of care
    • Requirement for therapy with calcitriol ≥0.5 mcg per day or alphacalcidol ≥1 mcg per day, and requirement for supplemental oral calcium treatment ≥1000 mg per day over and above patient's dietary calcium intake at Day 1 visit
    • Successful completion of the Optimization period based on two consecutive measurements of albumin-adjusted serum calcium at least 1 week apart within the range of 7.8 to 9.0 mg/dL and with no more than 25% of change in the daily dose of any of active vitamin D and oral calcium supplements between the two measurements
    • Thyroid-stimulating hormone (TSH) within the lower limit of normal and 1.5-fold of the upper limit of normal at screening; if on suppressive therapy for a history of thyroid cancer, TSH level must be ≥0.2 mIU/mL and thyroid medication should be stable for at least 6 weeks prior to treatment
    • Prior to start of treatment:
    • Magnesium level within laboratory normal limits
    • 25(OH) vitamin D levels of 30-70 ng/mL (75-175 nmol/L)
    • eGFR ≥30 mL/min/1.73m² during screening
    • Able to perform daily subcutaneous self-injections of study drug (or have a designee to perform injections) via a pre-filled injection pen
    • Female patients of non-childbearing potential or using an effective method of contraception throughout the study. Women of childbearing potential should have a negative pregnancy test.
    • Able and willing to provide written and signed informed consent in accordance with GCP
    Exclusion Criteria
    • Mental incapacity, unwillingness, or language barriers precluding adequate understanding or cooperation
    • Clinically significant abnormal values at screening for hematology, clinical chemistry, coagulation or urinalysis
    • Abnormal arterial pressure at screening, defined as (1) systolic blood pressure \<100 mmHg, or (2) systolic blood pressure \>150 mmHg, and/or diastolic blood pressure \>100 mmHg.
    • Heart rate at rest outside the range of 50-100 beats/minute at screening
    • Clinically significant abnormal standard 12-lead electrocardiogram indicative of severe cardiac disease
    • Known history of autosomal-dominant hypocalcemia or known pseudohypoparathyroidism (impaired responsiveness to PTH)
    • Any current disease (other than hypoparathyroidism) that might affect calcium metabolism, calcium-phosphate homeostasis or PTH levels
    • Patients with increased risk for osteosarcoma
    • Current uncontrolled active disease processes that may adversely affect gastrointestinal absorption
    • History of cerebrovascular accident within 6 months prior to screening
    • History of active uncontrolled malignancy over the past 2 years at time of screening
    • History of any other cancer other than thyroid cancer (except basal cell skin cancer or squamous cell skin cancer) who have not been disease-free for a period of at least 2 years at the time of screening
    • Acute gout \<2 months prior to screening
    • Dependent on parenteral calcium infusions to maintain calcium homeostasis
    • Use of medications such as loop and thiazide diuretics, raloxifene hydrochloride, lithium, methotrexate, cardiac glycosides or systemic corticosteroids within 4 weeks prior to start of treatment
    • Previous treatment with PTH/parathyroid hormone-related protein-like drugs, including PTH(1-84) and PTH(1-34) within 3 months of screening
    • Use of other drugs known to influence calcium and bone metabolism within 4 weeks of screening
    • Use of oral bisphosphonates within 6 months of screening or intravenous bisphosphonate within 12 months of screening
    • Use of denosumab within 18 months of screening
    • Seizure disorder/epilepsy with history of a seizure within 6 months of screening
    • History of symptomatic urinary tract calculi within 3 months of screening
    • Irradiation to the skeleton within 2 years of screening
    • Pregnant or breastfeeding female patients
    • Participation in any other interventional study in which the patient received an investigational drug or device within 2 months or within 5 times the half-life of the investigational drug (whichever comes first) prior to screening
    • Any disease or condition that, in the opinion of the investigator, may require treatment or make the subject unlikely to fully complete the trial, or any condition that presents undue risk from the study treatment or procedures, including treated malignancies that are likely to recur within the approximate duration of the trial
    • Any other reason that in the opinion of the investigator would prevent the subject from completing participation or following the trial schedule
    • Known allergy or sensitivity to PTH or any of the excipients
    Sex
    Female & Male
    Age
    18 - 80 Years

    Study Details

    Medical Condition
    • Unmapped
    Study Drug
      Date
      Jun 2023 - Nov 2024
      Phase 1
      Phase 2
      Phase 3
      Phase 4
      N/A
      Patient Requirements
      Sex: Female & Male
      Age: 18 - 80 Years years
      Requirements Information
      Inclusion and Exclusion Criteria
      Inclusion Criteria
      • Males and Females, 18-80 years of age
      • Patients with cHP for ≥12 months at the time of screening
      • Two paired measurements of showing low parathyroid hormone (PTH) and serum calcium either below normal or within normal under standard of care
      • Requirement for therapy with calcitriol ≥0.5 mcg per day or alphacalcidol ≥1 mcg per day, and requirement for supplemental oral calcium treatment ≥1000 mg per day over and above patient's dietary calcium intake at Day 1 visit
      • Successful completion of the Optimization period based on two consecutive measurements of albumin-adjusted serum calcium at least 1 week apart within the range of 7.8 to 9.0 mg/dL and with no more than 25% of change in the daily dose of any of active vitamin D and oral calcium supplements between the two measurements
      • Thyroid-stimulating hormone (TSH) within the lower limit of normal and 1.5-fold of the upper limit of normal at screening; if on suppressive therapy for a history of thyroid cancer, TSH level must be ≥0.2 mIU/mL and thyroid medication should be stable for at least 6 weeks prior to treatment
      • Prior to start of treatment:
      • Magnesium level within laboratory normal limits
      • 25(OH) vitamin D levels of 30-70 ng/mL (75-175 nmol/L)
      • eGFR ≥30 mL/min/1.73m² during screening
      • Able to perform daily subcutaneous self-injections of study drug (or have a designee to perform injections) via a pre-filled injection pen
      • Female patients of non-childbearing potential or using an effective method of contraception throughout the study. Women of childbearing potential should have a negative pregnancy test.
      • Able and willing to provide written and signed informed consent in accordance with GCP
      Exclusion Criteria
      • Mental incapacity, unwillingness, or language barriers precluding adequate understanding or cooperation
      • Clinically significant abnormal values at screening for hematology, clinical chemistry, coagulation or urinalysis
      • Abnormal arterial pressure at screening, defined as (1) systolic blood pressure \<100 mmHg, or (2) systolic blood pressure \>150 mmHg, and/or diastolic blood pressure \>100 mmHg.
      • Heart rate at rest outside the range of 50-100 beats/minute at screening
      • Clinically significant abnormal standard 12-lead electrocardiogram indicative of severe cardiac disease
      • Known history of autosomal-dominant hypocalcemia or known pseudohypoparathyroidism (impaired responsiveness to PTH)
      • Any current disease (other than hypoparathyroidism) that might affect calcium metabolism, calcium-phosphate homeostasis or PTH levels
      • Patients with increased risk for osteosarcoma
      • Current uncontrolled active disease processes that may adversely affect gastrointestinal absorption
      • History of cerebrovascular accident within 6 months prior to screening
      • History of active uncontrolled malignancy over the past 2 years at time of screening
      • History of any other cancer other than thyroid cancer (except basal cell skin cancer or squamous cell skin cancer) who have not been disease-free for a period of at least 2 years at the time of screening
      • Acute gout \<2 months prior to screening
      • Dependent on parenteral calcium infusions to maintain calcium homeostasis
      • Use of medications such as loop and thiazide diuretics, raloxifene hydrochloride, lithium, methotrexate, cardiac glycosides or systemic corticosteroids within 4 weeks prior to start of treatment
      • Previous treatment with PTH/parathyroid hormone-related protein-like drugs, including PTH(1-84) and PTH(1-34) within 3 months of screening
      • Use of other drugs known to influence calcium and bone metabolism within 4 weeks of screening
      • Use of oral bisphosphonates within 6 months of screening or intravenous bisphosphonate within 12 months of screening
      • Use of denosumab within 18 months of screening
      • Seizure disorder/epilepsy with history of a seizure within 6 months of screening
      • History of symptomatic urinary tract calculi within 3 months of screening
      • Irradiation to the skeleton within 2 years of screening
      • Pregnant or breastfeeding female patients
      • Participation in any other interventional study in which the patient received an investigational drug or device within 2 months or within 5 times the half-life of the investigational drug (whichever comes first) prior to screening
      • Any disease or condition that, in the opinion of the investigator, may require treatment or make the subject unlikely to fully complete the trial, or any condition that presents undue risk from the study treatment or procedures, including treated malignancies that are likely to recur within the approximate duration of the trial
      • Any other reason that in the opinion of the investigator would prevent the subject from completing participation or following the trial schedule
      • Known allergy or sensitivity to PTH or any of the excipients

      Protocol Summary

      This study is investigating the safety and efficacy of eneboparatide (AZP-3601) in patients with chronic hypoparathyroidism (cHP).

      During the first 24 weeks of the trial, participants will be randomized to receive eneboparatide or placebo. Study treatment is blinded: patients and doctors will not know which group each patient has been randomized to. All patients will start with a fixed dose of study treatment (eneboparatide or placebo), administered subcutaneously with a pre-filled pen. Study treatment will be individually titrated.

      After completion of the first 24 weeks, patients will be treated in the open label extension part of the study for 132 weeks. During this phase, all patients (including patients that were in the placebo group) will receive eneboparatide.

      Trial Locations

      Location
      Status
      Location
      Harbor UCLA Medical Center Endocrinology
      Torrance, California, United States, 90502
      Status
      N/A
      Location
      Denver Endocrinology Diabetes and Thyroid Center
      Denver, Colorado, United States, 80113
      Status
      N/A
      Location
      University of Chicago - Medical Center
      Chicago, Illinois, United States, 60637
      Status
      N/A
      Location
      North Shore University Health System
      Evanston, Illinois, United States, 60201
      Status
      N/A
      Location
      Indiana University (IU) Health University Hospital
      Indianapolis, Indiana, United States, 46202
      Status
      N/A
      Location
      Massachusetts General Hospital
      Boston, Massachusetts, United States, 02114
      Status
      N/A
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