A Proof-of-Concept Study of Danicopan for 6 Months of Treatment in Participants With C3 Glomerulopathy (C3G)
Study Identifier:
ACH471-204
ClinicalTrials.gov Identifier:
EudraCT Identifier:
EU CT ID:
N/A
Sponsor:
Alexion Pharmaceuticals, Inc.
Study Contact Information:
N/A
Study Complete
Available Documents
Study Details
Medical Condition
- Unmapped
Study Drug
- Drug: Danicopan
- Drug: Placebo
Date
Jun 2018 - Dec 2019
Phase 1
Phase 2
Phase 3
Phase 4
N/A
Patient Requirements
Sex: Female & Male
Age: 17 - 65 Years
Requirements Information
Inclusion and Exclusion Criteria
Inclusion Criteria
- Had biopsy-confirmed primary C3G
- Had clinical evidence of ongoing disease based on significant proteinuria, attributable to C3G disease in the opinion of the Principal Investigator (PI), and present prior to study entry and confirmed during Screening
- Was willing to comply with vaccination requirements.
Exclusion Criteria
- Had a history or presence of any clinically relevant co-morbidities that would make the participant inappropriate for the study
- Had ever received danicopan
- Had more than 50% fibrosis or more than 50% of glomeruli with cellular crescents on the pre-treatment renal biopsy
- Had an estimated glomerular filtration rate \<30 milliliters/minute/1.73 meters squared at the time of screening or at any time over the preceding 4 weeks
- Was a renal transplant recipient or receiving renal replacement therapy
- Had a history of a major organ transplant or hematopoietic stem cell/marrow transplant
- Had evidence of monoclonal gammopathy of unclear significance, infections, malignancy, autoimmune diseases, or other conditions to which C3G is secondary
- Had other renal diseases that would interfere with interpretation of the study
- Had been diagnosed with or showed evidence of hepatobiliary cholestasis
- Females who were pregnant, nursing, or planning to become pregnant during the study or within 90 days of study drug administration
- Had a history of febrile illness, a body temperature \>38°Celsius, or other evidence of a clinically significant active infection, within 14 days prior to study drug administration
- Had evidence of human immunodeficiency virus, hepatitis B infection, or active hepatitis C infection at Screening
- Had laboratory abnormalities at screening that, in the opinion of the PI, would make the participant inappropriate for the study
Sex
Female & Male
Age
17 - 65 Years
Study Details
Medical Condition
- Unmapped
Study Drug
- Drug: Danicopan
- Drug: Placebo
Date
Jun 2018 - Dec 2019
Phase 1
Phase 2
Phase 3
Phase 4
N/A
Patient Requirements
Sex: Female & Male
Age: 17 - 65 Years years
Requirements Information
Inclusion and Exclusion Criteria
Inclusion Criteria
- Had biopsy-confirmed primary C3G
- Had clinical evidence of ongoing disease based on significant proteinuria, attributable to C3G disease in the opinion of the Principal Investigator (PI), and present prior to study entry and confirmed during Screening
- Was willing to comply with vaccination requirements.
Exclusion Criteria
- Had a history or presence of any clinically relevant co-morbidities that would make the participant inappropriate for the study
- Had ever received danicopan
- Had more than 50% fibrosis or more than 50% of glomeruli with cellular crescents on the pre-treatment renal biopsy
- Had an estimated glomerular filtration rate \<30 milliliters/minute/1.73 meters squared at the time of screening or at any time over the preceding 4 weeks
- Was a renal transplant recipient or receiving renal replacement therapy
- Had a history of a major organ transplant or hematopoietic stem cell/marrow transplant
- Had evidence of monoclonal gammopathy of unclear significance, infections, malignancy, autoimmune diseases, or other conditions to which C3G is secondary
- Had other renal diseases that would interfere with interpretation of the study
- Had been diagnosed with or showed evidence of hepatobiliary cholestasis
- Females who were pregnant, nursing, or planning to become pregnant during the study or within 90 days of study drug administration
- Had a history of febrile illness, a body temperature \>38°Celsius, or other evidence of a clinically significant active infection, within 14 days prior to study drug administration
- Had evidence of human immunodeficiency virus, hepatitis B infection, or active hepatitis C infection at Screening
- Had laboratory abnormalities at screening that, in the opinion of the PI, would make the participant inappropriate for the study
Protocol Summary
The primary purpose of this proof-of-concept clinical study was to evaluate the efficacy and safety of the study drug, ACH-0144471 (also known as danicopan and ALXN2040), in participants with C3G who also had significant proteinuria attributable to C3G.
Trial Locations
Location
Status
Location
Clinical Study Site
Aurora, Colorado, United States, 80045
Status
N/A
Location
Clinical Study Site
Lawrenceville, Georgia, United States, 30046
Status
N/A
Location
Clinical Study Site
Iowa City, Iowa, United States, 52242
Status
N/A
Location
Clinical Study Site
Baltimore, Maryland, United States, 21205
Status
N/A
Location
Clinical Study Site
New York, New York, United States, 10016
Status
N/A
Location
Clinical Study Site
New York, New York, United States, 10032
Status
N/A
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